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Common Health Guidelines (Non-Cancer) Used by ATSDRĬommon Health Guidelines Health GuidelinesĪTSDR-Developed Minimal Risk Levels (MRLs) The values do not represent thresholds of toxicity. Health guidelines (used to evaluate non-cancer health effects) ( see descriptions in this table) and cancer risk values (used to estimate cancer risks) ( see descriptions in this table) are derived from data in the epidemiologic and toxicologic literature with appropriate uncertainty or safety factors applied to ensure they are set at levels below those that could result in harmful health effects. Different health guidelines are available for exposure routes (ingestion, inhalation), exposure durations (acute, subchronic/intermediate, and chronic), and health endpoints (carcinogenic, non-carcinogenic). Important: PHAST will make this selection for you, but it is important for health assessors to understand ATSDR’s selection process. Selecting Appropriate Health Guidelines and Cancer Risk Valuesīefore performing the HQ and CR calculations, you will need to determine the most appropriate health guidelines or cancer risk values, respectively, to use for evaluating your site-specific exposure doses or adjusted air concentrations.

Once you have your estimated exposure doses and adjusted air concentrations, you will use health guidelines and cancer risk values to estimate the potential non-cancer health effects and cancer risks, respectively, for each contaminant and exposure pathway.